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博士生导师简介

 

王克剑

专业学科:作物种质资源学

研究方向:作物种质资源创新与利用

 

王克剑,研究员,博士生导师,1983年12月生,江苏盐城人。中国农业科学院水稻染色体工程及基因组编辑创新团队,首席科学家;中国水稻研究所基因资源挖掘与利用研究室,课题组长。

2004年毕业于扬州大学,获农学学士学位;2009年毕业于中国科学院遗传与发育生物学研究所,获理学博士学位并留所工作,先后任助理研究员、副研究员;主要围绕水稻减数分裂和花发育分子机制开展基础研究。2013年8月至中国水稻研究所任课题组长,主要围绕基因组编辑和遗传重组开展应用基础研究。自独立开展工作以来,以通讯作者在Molecular Plant, Plant Biotechnology Journal 等期刊上发表论文10余篇;现任中国细胞生物学学会染色质生物学分会委员、中国遗传学会基因组编辑分会委员、BMC Plant Biology、生物技术通报(英文版)等期刊编委。

主要研究方向

  1. 基因组编辑技术体系研发及应用;

  2. 遗传重组机制及应用研究;

  3. 基因组学大数据挖掘。

近年发表的主要论文

*通讯作者论文

  1. Hu, X#., Meng, X#., Liu, Q., Li, J*., and Wang K*.(2018). Increasing the efficiency of CRISPR-Cas9-VQR precise genome editing in rice. Plant Biotechnology Journal 16: 292-297 (IF=6.305,其中第一作者胡熙璕为农业推广硕士;中文简介:http://www.caas.net.cn/xwzx/kyjz/283344.html)

  2. Shen, L#., Wang, C#., Fu, Y., Wang, J., Liu, Q., Zhang, X., Yan, C*., Qian, Q*., and Wang, K*. (2018). QTL editing confers opposing yield performance in different rice varieties. Journal of Integrative Plant Biology61: 122-125(IF=3.085,中文简介:http://www.caas.net.cn/ysxw/kyjz/275281.shtml)

  3. Meng, X#., Hu, X#., Liu, Q., Song, X., Gao, C., Li, J*., and Wang, K*. (2018) Robust genome editing of CRISPR-Cas9 at NAG PAMs in rice. Science China Life Sciences 61: 122-125 (IF= 3.085,其中第一作者胡熙璕为农业推广硕士)

  4. Hua, Y#., Wang, C#., Huang, J#., and Wang, K*. (2017). A simple and efficient method for CRISPR/Cas9 mutant screening. Journal of Genetics and Genomics(当年IF=4.066,中文简介:http://www.caas.net.cn/ysxw/kyjz/281001.shtml)

  5. Shen, L#., Hua, Y#., Fu, Y#., Li, J#., Liu, Q., Jiao, X., Xin, G., Wang, J., Wang, X., Yan, C*., and Wang, K*. (2017). Rapid generation of genetic diversity by multiplex CRISPR/Cas9 genome editing in rice. Science China Life Sciences 5: 506-515(当年IF=3.085,基因编辑专刊约稿)

  6. Hu, X#., Wang, C#., Liu, Q., Fu, Y., and Wang, K*. (2017). Targeted mutagenesis in rice using CRISPR-Cpf1 system. Journal of Genetics and Genomics 44, 71-73. (当年IF=4.066,其中第一作者胡熙璕为农业推广硕士;中文简介:http://www.caas.net.cn/ysxw/kyjz/277667.shtml)

  7. Hu, X#., Wang, C#., Fu, Y#., Liu, Q., Jiao, X., and Wang, K*. (2016). Expanding the Range of CRISPR/Cas9 Genome Editing in Rice. Molecular Plant, 9, 943-945. (当年IF=8.827,其中第一作者胡熙璕为农业推广硕士;中文简介:http://www.caas.net.cn/ysxw/kyjz/268716.shtml)

  8. Wang, C#., Shen, L#., Fu, Y., Yan, C., Wang, K*. A Simple CRISPR/Cas9 System for Multiplex Genome Editing in Rice. Journal of Genetics and Genomics, 2015, 42:703-706. (当年IF=3.981,中文简介:http://www.caas.net.cn/ysxw/kyjz/262667.shtml)

  9. Wang, K*., Wang, C., Liu, Q., Fu, Y. Increasing the Genetic Recombination Frequency by Partial Loss of Function of the Synaptonemal Complex in Rice. Molecular Plant, 2015, 8: 1295-1298.(当年IF=7.142,中文简介:http://www.caas.net.cn/ysxw/kyjz/255650.shtml)

其它论文

  1. Che, L#., Wang, K#(共同第一)., Tang, D., Liu, Q., Chen, X., Li, Y., Hu, Q., Shen, Y., Yu, H., Gu, M., et al.. OsHUS1 Facilitates Accurate Meiotic Recombination in Rice. PLoS Genetics, 2014, 10:e1004405.(当年IF=8.167)

  2. Wang, K (第一作者)., Wang, M., Tang, D., Shen, Y., Miao, C., Hu, Q., Lu, T., Cheng, Z.. The role of HEI10 in crossover formation in rice. PLoS Genetics, 2012, 8:e1002809.(当年IF=8.517)

  3. Wang, K (第一作者)., Wang, M., Tang, D., Shen, Y., Qin, B., Li, M., and Cheng, Z.. PAIR3, an axis-associated protein, is essential for the recruitment of recombination elements onto meiotic chromosomes in rice. Molecular Biology of the Cell, 2011, 22:12-19.(当年IF=4.942)

  4. Wang, K (第一作者)., Tang, D., Hong, L., Xu, W., Huang, J., Li, M., Gu, M., Xue, Y., Cheng, Z.. DEPand AFO regulate reproductive habit in rice. PLoS Genetics, 2010, 6:e1000818.(封面文章,当年IF=9.543)

  5. Wang, K (第一作者)., Tang, D., Wang, M., Lu J., Yu, H., Liu, J., Qian, B., Gong, Z., Wang, X., Chen, J., Gu, M., and Cheng, Z.. MER3 is required for normal meiotic crossover formation, but not for presynaptic alignment in rice. Journal of Cell Science, 2009, 122:2055-2063.(当年IF=6.144)

  6. Wang, M., Wang, K., Tang, D., Wei, C., Li, M., Shen, Y., Chi, Z., Gu, M., Cheng, Z.. The Central Element Protein ZEP1 of the Synaptonemal Complex Regulates the Number of Crossovers during Meiosis in Rice. The Plant Cell, 2010, 22:417-430.(当年IF=9.396)

  7. Hong, L., Tang, D., Zhu, K., Wang, K., Li, M., and Cheng, Z.. Somatic and Reproductive Cell Development in Rice Anther Is Regulated by a Putative Glutaredoxin. The Plant Cell, 2012, 24:577-588.(当年IF=9.251)

  8. Wang, M., Tang, D., Luo, Q., Jin, Y., Shen, Y., Wang, K., Cheng, Z.. BRK1, a Bub1-related kinase, is essential for generating proper tension between homologous kinetochores at metaphase I of rice meiosis. The Plant Cell, 2012, 24:4961-4973.(当年IF=9.251)

  9. Wu, X., Tang, D., Li, M., Wang, K., Cheng, Z.. Loose plant architecture 1, an INDETERMINATE domain protein involved in shoot gravitropism, regulates plant architecture in rice. Plant Physiology, 2013, 161:317-329.(当年IF=7.394)

  10. Luo, Q., Tang, D., Wang, M., Luo, W., Zhang, L., Qin, B., Shen, Y., Wang, K., Li, Y., Cheng, Z. The role of OsMSH5 in crossover formation during rice meiosis. Molecular Plant, 2013, 6:729-742.(当年IF=6.605)

  11. Ji, J., Tang D., Wang, M., Li, Y., Zhang L, Wang, K., Li, M., and Cheng, Z.. MRE11 is required for homologous synapsis and DSB processing in rice meiosis. Chromosoma, 2013, 122:363-376.(当年IF=3.260)

  12. Ji, J., Tang, D., Wang, K., Wang, M., Che, L., Li, M., Cheng, Z.. The role of OsCOM1 in homologous chromosome synapsis and recombination in rice meiosis. The Plant Journal, 2012, 72:18-30.(当年IF=6.582)

  13. Shen, Y., Tang, D., Wang, K., Wang, M., Huang, J., Luo, W., Luo, Q., Hong, L., Li, M., Cheng, Z.. The Role of ZIP4 in Homologous Chromosome Synapsis and Crossover Formation in Rice Meiosis. Journal of Cell Science, 2012, 125:2581-2591.(当年IF=5.877)

  14. Hong, L., Qian, Q., Tang, D., Wang, K., Li, M., and Cheng, Z.. A mutation in the rice chalcone isomerase gene causes the golden hull and internode 1 phenotype. Planta, 2012, 236:141-151.(当年IF=3.347)

  15. Hong, L., Tang, D., Shen, Y., Hu, Q., Wang, K., Li, M., Lu, T., and Cheng, Z.. MIL2 (MICROSPORELESS2) regulates early cell differentiation in the rice anther. New Phytologist, 2012, 196:402-413.(当年IF=6.736)

  16. Che, L., Tang, D., Wang, K., Wang, M., Zhu, K., Yu, H., Gu, M., and Cheng, Z.. OsAM1 is required for leptotene-zygotene transition in rice. Cell Research, 2011, 21:654-665.(当年IF=8.19)

  17. Shao, T., Tang, D., Wang, K., Wang, M., Che, L., Qin, B., Yu, H., Li, M., Gu, M., and Cheng, Z.. OsREC8 is essential for chromatid cohesion and metaphase I monopolar orientation in rice meiosis. Plant Physiology, 2011, 156:1386-1396.(当年IF=6.535)

  18. Wang, M., Tang, D., Wang, K., Shen, Y., Qin, B., Miao, C., Li, M., and Cheng, Z.. OsSGO1 maintains synaptonemal complex stabilization in addition to protecting centromeric cohesion during rice meiosis. The Plant Journal, 2011, 67:583-594.(当年IF=6.160)

  19. Li, M., Tang, D., Wang, K., Wu, X., Lu, L., Yu, H., Gu, M., Yan, C., and Cheng, Z.. Mutations in the F-box gene LARGER PANICLE improve the panicle architecture and enhance the grain yield in rice. Plant Biotechnology Journal, 2011, 9:1002-1013.(当年IF=5.442)

  20. Qin, B., Tang, D., Huang, J., Li, M., Wu, X., Lu, L., Wang, K., Yu, H., Chen, J., Gu, M., and Cheng, Z.. Rice OsGL1-1 is involved in leaf cuticular wax and cuticle membrane. Molecular Plant, 2011, 4:985-995.(当年IF=5.546)

  21. Yu, H., Wang, M., Tang, D., Wang, K., Chen, F., Gong, Z., Gu, M., and Cheng, Z.. OsSPO11-1 is essential for both homologous chromosome pairing and crossover formation in rice. Chromosoma, 2010, 119:625-636.(当年IF=4.196)

通讯地址:浙江省杭州市体育场路359号 中国水稻研究所 310006

电  话:0571-63370202

电子邮箱:wangkejian@caas.cn


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内容更新日期:2018-10-01