一、个人简介

胡时开，博士，研究员，博导，主要从事优质多抗新种质创制和新品种培育、稻米营养安全品质遗传改良等工作。现任国家农业生物育种重大项目技术首席，先后主持国家农业生物育种重大项目课题、国家自然科学基金、浙江省农业关键核心技术攻关重大项目、浙江省自然科学基金重大项目等国家、省部级以上项目共计10余项；获神农中华农业科技奖1项，参与培育优质抗病水稻新品种10余个，获植物新品种权5项，国家授权专利15项；以第一作者或通讯作者（含共同）在Molecular Plant、Plant Biotechnology Journal、Journal of Hazardous Materials、Plant Physiology等国内外刊物上发表研究论文40余篇，参与《水稻分子育种技术指南》的撰写。

二、主要研究方向：

1. 水稻优质多抗新种质创制与新品种培育；

2. 稻米营养与安全品质关键基因挖掘及育种利用。

三、承担项目：

1. 国家农业生物育种重大专项课题，主持，执行期2022-2025。

2. 国家自然科学基金面上项目，主持，32071991，执行期2021-2024。

3. 中国农业科学院“青年英才”培育工程项目，主持，NKYCQN-2021-29，执行期2022-2027。

4. 浙江省自然科学基金重大项目/青年原创项目，主持，执行期2023-2025。

5. 浙江省HXGG重大项目，主持，执行期2024-2028。

6. 国家自然科学基金面上项目，主持，31872861，执行期2019-2022。

7. 国家自然科学基金委青年科学基金，主持，31501279，执行期2016-2018。

8. 国家自然科学基金委面上项目，主要参与者/负责项目执行，31972961，执行期2020-2023。

9. 浙江省重点研发“尖兵计划”，主要参与者/负责项目执行，2022C02011，执行期2022-2024。

四、代表成果：

获神农中华农业科技奖1项，参与培育优质抗病水稻新品种10余个，获植物新品种权5项，国家授权专利15项。

五、代表论文

1. Shikai Hu#, *, Liang Zhou#, Jingxin Wang, Amos Musyoki Mawia, Suozhen Hui, Bo Xu, Guiai Jiao, Zhonghua Sheng, Gaoneng Shao, Xiangjin Wei, Ling Wang, Lihong Xie, Fengli Zhao, Shaoqing Tang*, Peisong Hu*. Production of Grains with Ultra-low Heavy Metal Accumulation by Pyramiding Novel Alleles of OsNramp5 and OsLsi2 in Two-line Hybrid Rice. Plant Biotechnology Journal,2024, 22(10):2921-2931. doi: 10.1111/pbi.14414.  

2. Shikai Hu *, #, Lingwei Yang #, Jinyang Cai #, Guiai Jiao, Hailong Yang, Suozhen Hui, Liang Zhou, Ruijie Cao, Jingxin Wang, Yujuan Chen, Junchao Fang, Zhonghua Sheng, Shaoqing Tang*, Peisong Hu*. Production of Grains with Low-glutelin and High Eating Quality by using Dominant Allele Lgc-1 in Three-line Japonica Hybrid Rice. Plant Biotechnology Journal, 2025, 23(2)：374-376. DOI: 10.1111/pbi.14502

3. Shikai Hu, Xingming Hu, Jiang Hu, Lianguang Shang, Guojun Dong, Dali Zeng, Longbiao Guo, Qian Qian*. Xiaowei, A New Rice Germplasm for Large-Scale Indoor Research. Molecular Plant, 2018, 11(11): 1418-1420.  

4. Suozhen Hui #, Huijuan Li#, Amos Musyoki Mawia#, Liang Zhou, Jinyang Cai, Shakeel Ahmad, Changkai Lai, Jingxin Wang, Guiai Jiao, Lihong Xie, Gaoneng Shao, Zhonghua Sheng, Shaoqing Tang, Jianlong Wang, Xiangjin Wei*, Shikai Hu*, Peisong Hu*. Production of aromatic three-line hybrid rice using novel alleles of BADH2. Plant Biotechnology Journal, 2022, 20(1): 59-74.

5. Jingxin Wang#, Lingwei Yang#, Bo Xu#, Ruijie Cao, Sidra Charagh, Suozhen Hui, Liang Zhou, Yuanyuan Zhang, Yujuan Chen, Zhonghua Sheng, Guiai Jiao, Gaoneng Shao, Ling Wang, Fengli Zhao, Lihong Xie, Yusong Lyu, Shaoqing Tang*, Shikai Hu*, Peisong Hu*. Chloroplast-localized transporter OsNTP1 mediates cadmium transport from root to shoot and sugar metabolism in rice. Journal of Hazardous Materials, 2025, 484: 136766 . https://doi.org/10.1016/j.jhazmat.2024.136766

6. Amos Musyoki Mawia#, Suozhen Hui#, Liang Zhou#, Huijuan Li, Javaria Tabassum, Changkai Lai, Jingxin Wang, Gaoneng Shao, Xiangjin Wei, Shaoqing Tang, Ju Luo*, Shikai Hu*, Peisong Hu*. Inorganic Arsenic Toxicity and Alleviation Strategies in Rice. Journal of Hazardous Materials, 2021, 408：124751.

7. Ting Mao#, Mingdong Zhu#, Zhonghua Sheng, Gaoneng Shao, Guiai Jiao, Amos Musyoki Mawia, Shakeel Ahmad, Lihong Xie, Shaoqing Tang, Xiangjin Wei, Shikai Hu*, Peisong Hu*. Effects of grain shape genes editing on appearance quality of erect-panicle Geng/Japonica rice. Rice, 2021, 14, 74.

8. Lingwei Yang#，Junchao Fang#，Jingxin Wang#，Suozhen Hui，Liang Zhou，Bo Xu，Yujuan Chen，Yuanyuan Zhang，Changkai Lai，Guiai Jiao, Zhonghua Sheng, Xiangjin Wei, Gaoneng Shao, Lihong Xie, Ling Wang, Ying Chen, Fengli Zhao, Shikai Hu*, Peisong Hu*, Shaoqing Tang* . Genome-Wide Identification and Expression Analysis of 3-Ketoacyl-CoA Synthase Gene Family in Rice (Oryza sativa L.) Under Cadmium Stress. Frontiers in Plant Science, 2023, 14:1222288. doi: 10.3389/fpls.2023.1222288

9. Mao Ting, Li Xin, Liu Yan, Zhong Shuncheng, Wang Shiyu, Li Xu, Hu Shikai*. (2023) Effect of GW8 Gene Editing on the Appearance Quality of Erect-panicle Type (dep1) Japonica Rice. Rice Science, 2023, 30(5): 359−363.

10. Shakeel Ahmad, Javaria Tabassum, Zhonghua Sheng, Yusong Lv, Wei Chen, Aqib Zeb, Nannan Dong, Gaoneng Shao, Xiangjin Wei, Shikai Hu*, Shaoqing Tang*. Loss-of-function of PGL10 impairs photosynthesis and tolerance to high-temperature stress in rice. Physiologia Plantarum. 2024, 176:e14369.

11. Sidra Charagh, Suozhen Hui, Jingxin Wang, Ali Raza, Liang Zhou, Bo Xu, Yuanyuan Zhang, Zhonghua Sheng, Shaoqing Tang, Shikai Hu*, Peisong Hu*.Unveiling Innovative Approaches to Mitigate Metals/Metalloids Toxicity for Sustainable Agriculture. Physiologia Plantarum, 2024, 176:e14226

12. Shakeel Ahmad#, Liqun Tang#, Rahil Shahzad, Amos Musyoki Mawia, Gundra Sivakrishna Rao, Shakra Jamil, Chen Wei, Zhonghua Sheng, Gaoneng Shao, Xiangjin Wei, Peisong Hu, Magdy M. Mahfouz, Shikai Hu*, Shaoqing Tang*. (2021) CRISPR-based crop improvements: A way forward to achieve zero hunger. Journal of Agricultural and Food Chemistry, 69 (30), 8307-8323.

13. Liwen Wu#, Deyong Ren#, Shikai Hu#, Gengmi Li#, Guojun Dong, Liang Jiang, Xingming Hu, Weijun Ye, Yongtao Cui, Li Zhu, Jiang Hu, Guangheng Zhang, Zhenyu Gao, Dali Zeng, Qian Qian*, and Longbiao Guo*. Down-regulation of a nicotinate phosphoribosyltransferase gene, OsNaPRT1, leads to withered leaf tips. Plant Physiology, 2016, 171: 1085-1098.

14. Shikai Hu#, Guojun Dong#, Jie Xu, Yan Su, Zhengyuan Shi, Weijun Ye, Yuanyuan Li, Gengmi Li, Bin Zhang, Jiang Hu, Qian Qian, Dali Zeng*, Longbiao Guo*. A point mutation in the zinc finger motif of RID1/EHD2/OsID1 protein leads to outstanding yield-related traits in japonica rice variety Wuyunjing 7. Rice, 2013, 6: 24.

15. Su Yan#, Rao YuChun#, Hu Shikai#, Yang Yaolong, Gao Zhenyu, Zhang Guangheng, Liu Jian, Hu Jiang, Yan Meixian, Dong Guojun, Zhu Li, Guo Longbiao, Qian Qian*, Zeng Dali*. Map-based cloning proves qGC-6, a major QTL for gel consistency of japonica/indica cross, was responded by Waxy in rice (Oryza sativa L.). Theoretical and Applied Genetics, 2011, 123: 859-867.

16. Haiyan Lin#, Shikai Hu#, Ruifang Liu, Ping Chen, Changwei Ge, Bo Zhu, Longbiao Guo*. Genome sequence of Pseudomonas koreensis CRS05-R5, an antagonistic bacterium isolated from rice paddy field. Frontiers in Microbiology, 2016, 7: 1756.

17. Kaizhen Zhong, Peng Zhang, Xiangjin Wei, Matthieu Pierre Platre, Wenrong He, Ling Zhang, Anna Małolepszy, Min Cao, Shikai Hu, Shaoqing Tang, Baohai Li*, Peisong Hu* & Wolfgang Busch* .Natural variation of TBR confers plant zinc toxicity tolerance through root cell wall pectin methylesterification. Nature Communications, 2024, 15, 5823. https://doi.org/10.1038/s41467-024-50106-5

18. 胡时开, 胡培松*. 功能稻米研究现状与展望. 中国水稻科学, 2021, 35(4): 311-325.

六、联系方式

通讯地址：浙江省杭州市富阳区水稻所路28号 中国水稻研究所 311401

电 话：15068820236

电子邮箱：hushikai@caas.cn