生物农药研究

组长：冯国忠

电话：0571-63370220

邮箱：fengguozhong;caas.cn

所属部门：水稻生物育种全国重点实验室

主要研究方向：

1.病毒复制的研究：重点研究杆状病毒的复制和水稻病毒的复制,以及微生物代谢产物抑制病毒复制的机理。

2.微生物代谢产物的抗病毒研究：微生物代谢产物的抗病毒筛选，活性代谢产物基因簇分离及其生物组合合成。

承担的科研项目：

浙江省重点研发计划，防治水稻纹枯病新型生物农药阳城菌素的研发及其示范应用，2021.01-2024.11

国家自然科学基金面上项目，杆状病毒Me53出核机理的研究，2020.01-2023.12

国家自然科学基金面上项目，杆状病毒DNA聚合酶入核机理的研究，2016.01-2019.12

中国农业科学院创新团队项目，“微生物资源与生物农药”创新团队，2015.01-2019.12

中国农业科学院“青年英才计划”项目，水稻生物农药的研究，2014.10-2019.09

中国农业科学院增量项目，Sf9细胞α输入蛋白的研究，2015.01-2016.12

专家类别

中国农业科学院“青年英才计划”A类入选者。

中国农业科学院“微生物资源与生物农药”创新团队首席科学家。

国际合作

1.加拿大圭尔夫大学（University of Guelph）的Peter Krell教授和 Baozhong Meng教授。

2.加拿大大湖森林中心（Great Lake Forestry Centre）的Basil Arif研究员以及Guoxin Quan研究员。

代表性论文(✻ 为通讯作者)

1.Wang H, Cao S, Yan Q...Feng G*. Genetic diversity of RNA viruses infecting invertebrate pests of rice.  Sci China Life Sci. 2023.

2.Yan Q, Xu Y, Zhong Z, Xu Y, Lin X, Cao Z, Feng G*. Insights into antibiotic resistance-related changes in microbial communities, resistome and mobilome in paddy irrigated with reclaimed wastewater. Sci Total Environ. 2023.

3.Chen G, Li P, Yan Q, Wu Y, Wang H, Chao S, Wu L, Chen L, Feng G*. Identification of Spodoptera frugiperda importin alphas that facilitate the nuclear import of Autographa californica multiple nucleopolyhedrovirus DNA polymerase. Insect Mol Biol. 2021. doi: 10.1111/imb.12704

4.Yan Q, Xu Y, Chen L, Cao Z, Shao Y, Xu Y, Yu Y, Fang C, Zhu Z, Feng G*, Chen M. Irrigation with secondary municipal-treated wastewater: Potential effects, accumulation of typical antibiotics and grain quality responses in rice (Oryza sativa L.). J Hazard Mater. 2021,15;410:124655. doi: 10.1016/j.jhazmat.2020.124655.

5.Chen G, Yan Q, Wang H, Chao S, Wu L, Krell PJ, Feng G* Identification and characterization of the nucleolar localization signal of Autographa californica multiple nucleopolyhedrovirus LEF5. J Virol, 2020, 94: e01891-19.

6.Chen G, Fang Y, Yan Q, Li P, Wu L, Feng G* The deficiency in nuclear localization signal of Neodiprion lecontei nucleopolyhedrovirus DNA polymerase prevents rescue of viral DNA replication and virus production in dnapol-null Autographa californica multiple nucleopolyhedrovirus. Virus Res, 2019, 266, 52-57.

7.Yan Q, Xu Y, Yu Y, Zhu ZW, Feng G✻. Effects of pharmaceuticals on microbial communities and activity of soil enzymes in mesocosm-scale constructed wetlands. Chemosphere. 2018, 18;212:245-253. doi: 10.1016/j.chemosphere.

8.Chen G, Yan Q, Fang Y, Wu L, Krell PJ, Feng G✻. The N terminus of Autographa californica Multiple Nucleopolyhedrovirus DNA Polymerase is Required for Efficient Viral DNA Replication and Virus and Occlusion Body Production. J Virol. 2018, doi: 10.1128/JVI.00398-18.

9.Yan Q, Min J, Yu Y, Zhu Z, Feng G✻. Microbial community response during the treatment of pharmaceutically active compounds (PhACs) in constructed wetland mesocosms. Chemosphere. 2017. doi: 10.1016/j.chemosphere.2017.08.064.

10.Yan Q, Gao X, Guo J, Zhu ZW, Feng G✻. Insights into the molecular mechanism of the responses for Cyperus alternifolius to PhACs stress in constructed wetlands. Chemosphere. 2016, 164:278-289.

11.Chen G, Fang Y, Wu L, Hu Z, Krell P J., Feng G✻. The DNA polymerase of Spodoptera litura nucleopolyhedroviruses: rescue of dnapol-null Autographa californica mutiple nucleopolyhedroviruses and identification of a nuclear localization signal. Journal of General Virology, 2016 . 97(8):1968-80.

12.Yan Q, Feng G✻, Gao X, Sun C, Guo JS, Zhu Z. Removal of pharmaceutically active compounds (PhACs) and toxicological response of Cyperus alternifolius exposed to PhACs in microcosm constructed wetlands. J Hazard Mater. 2016. 15;301:566-75

13. FengG, Krell P J.. Autographa californica Multiple Nucleopolyhedrovirus DNA Polymerase C-terminus is Required for Nuclear Localization and Viral DNA Replication. Journal of Virology, 2014, 88(18):10918-33.

通讯地址：浙江省杭州市体育场路359号 中国水稻研究所（310006）

浙江省杭州市富阳区新桥水稻所路28号 中国水稻研究所（311400）

电　　话：0571-63370220

电子邮箱：fengguozhong @caas.cn