水稻病原菌互作

组长：寇艳君

电话：0571-63501170

邮箱：kouyanjun@caas.cn

所属部门：水稻生物育种全国重点实验室

课题组长简介：

寇艳君，中国水稻研究所研究员，博士研究生导师。2011年12月获得华中农业大学生化与分子生物学博士学位，而后前往新加坡淡马锡生命科学研究所从事稻瘟菌的功能基因组学以及细胞生物学研究。2016年11月加入中国水稻研究所组建水稻–病原菌互作组，长期开展病原真菌-水稻-环境因子互作研究工作。近三年，以通讯/共同通讯作者在Molecular Plant、Trends in Plant Science、New Phytologist及Plant Communications等学术杂志上发表论文20余篇，先后主持了十四五国家重点研发计划青年科学家、国家自然科学基金国际合作与交流、面上和青年项目以及浙江省杰出青年基金等项目，获授权发明专利8件，兼任浙江省植物病理学会常务理事、浙江省植物病理学会青委会副主任及BMC Plant Biology等多个国际期刊的副主编或编委。

研究方向及内容：

1． 稻瘟菌-水稻-环境因子互作的分子机制研究及应用。

2． 抗稻曲病资源的挖掘与利用，抗稻曲病机制解析。

课题组论文：

1. Huanbin Shi#; Shuai Meng#; Shuwei Xie; Jiehua Qiu; Nan Jiang; Yanjun Kou*; UvSnx4 is required for conidiation, pathogenicity and stress responses by regulating mitophagy and macroautophagy in Ustilaginoidea virens, Crop Health, 2023, 1:2.

2. Chun Wang; Kejian Wang; Yanjun Kou*; Genome editing creates disease-resistant crops without yield penalties, Trends in Plant Science, 2024, 当年影响因子 20.5

3. Huanbin Shi; Hui Wen; Shuwei Xie; Yuan Li; Ya Chen; Zhiquan Liu; Nan Jiang, Jiehua Qiu; Xueming Zhu; Fucheng Lin; Yanjun Kou*; Antifungal activity and mechanisms of AgNPs and its combination with azoxystrobin against Magnaporthe oryzae, Environmental Science: Nano, 2023, 当年影响因子 7.3

4. Hui Wen; Shuai Meng; Shuwei Xie; Huanbin Shi; Jiehua Qiu; Nan Jiang; Yanjun Kou*; Sucrose non-fermenting protein kinase gene UvSnf1 is required for virulence in Ustilaginoidea virens, Virulence, 2023, 14(1):2235460. 当年影响因子 5.2

5. Jiehua Qiu; Ya Chen; Zhiquan Liu; Hui Wen; Nan Jiang; Huanbin Shi; Yanjun Kou*; Application of zinc oxide nanoparticles: an effective strategy to protect rice from rice blast and abiotic stresses, Environmental Pollution, 2023, 331(Pt 1):121925.当年影响因子 8.9

6. Zhiquan Liu; Jiehua Qiu; Zhenan Shen; Congcong Wang; Nan Jiang; Huanbin Shi; Yanjun Kou*; The E3 ubiquitin ligase OsRGLG5 targeted by the Magnaporthe oryzae effector AvrPi9 confers basal resistance against rice blast, Plant Communications, 2023, 4(5):100626. 当年影响因子10.5

7. Zhongling Wu; Huanbin Shi; Yuan Li; Fei Yan; Ziyue Sun; Chuyu Lin; Mengting Xu; Fucheng Lin; Yanjun Kou*; Zeng Tao*; Transcriptional regulation of autophagy-related genes by Sin3 negatively modulates autophagy in Magnaporthe oryzae, Microbiology Spectrum, 2023, e0017123.当年影响因子 3.7

8. Hui Wen#; Huanbin Shi#; Nan Jiang; Jiehua Qiu; Fucheng Lin; Yanjun Kou*; Antifungal mechanisms of silver nanoparticles on mycotoxin producing rice false smut fungus, iScience, 2022, 26(1):105763. 当年影响因子 5.8

9. Jiehua Qiu; Zhiquan Liu; Junhui Xie; Bo Lan; Zhenan Shen; Huanbin Shi; Fucheng Lin; Xiangling Shen; Yanjun Kou*; Dual impact of ambient humidity on the virulence of Magnaporthe oryzae and basal resistance in rice, Plant, Cell & Environment, 2022, 45(12):3399-341.当年影响因子 7.3

10. Chuyu Lin#; Zhongling Wu#; Huanbin Shi; Jinwei Yu; Mengting Xu; Fucheng Lin; Yanjun Kou*; Zeng Tao*; The additional PRC2 subunit and Sin3 histone deacetylase complex are required for the normal distribution of H3K27me3 occupancy and transcriptional silencing in Magnaporthe oryzae, New Phytologist, 2022, 236(2):576-589. 当年影响因子 9.4

11. Jiehua Qiu; Junhui Xie; Ya Chen; Zhenan Shen; Huanbin Shi; Naweed I. Naqvi; Qian Qian; Yan Liang; Yanjun Kou*; Warm temperature compromises JA-regulated basal resistance to enhance Magnaporthe oryzae infection in rice, Molecular Plant, 2022, 15(4):723-739. 当年影响因子 27.5

12. Shuai Meng#; Huanbin Shi#; Chuyu Lin; Zhongling Wu; Fucheng Lin; Zeng Tao *; Yanjun Kou*; UvKmt2-mediated H3K4 trimethylation is required for pathogenicity and stress response in Ustilaginoidea virens, Journal of Fungi, 2022, 8(6): 553. 当年影响因子 4.7

13. Shuai Meng; Jane Sadhna Jagernath; Chaoxi Luo; Huanbin Shi; Yanjun Kou*; MoWhi2 mediates mitophagy to regulate conidiation and pathogenesis in Magnaporthe oryzae, International Journal of Molecular Sciences, 2022, 23(10):5311. 当年影响因子 5.6

14. Zhongling Wu#; Jiehua Qiu#; Huanbin Shi; Chuyu Lin; Jiangnan Yue; Zhiquan Liu; Wei Xie; Naweed I. Naqvi; Yanjun Kou*; Zeng Tao *; Polycomb Repressive Complexes 2-mediated H3K27 trimethylation is required for pathogenicity in Magnaporthe oryzae, Rice Science, 2022, 29(4): 363-374. 当年影响因子 4.8

15. Shuai Meng#; Jiehua Qiu#; Meng Xiong#; Zhiquan Liu; Jane Sadhna Jagernath; Fucheng Lin; Huanbin Shi*; Yanjun Kou*；UvWHI2 is required for stress response and pathogenicity in Ustilaginonidea virens, Rice Science, 2022, 29 (1): 47-54. 当年影响因子 4.8

16. Shuai Meng#; Zhiquan Liu#; Huanbin Shi#; Zhongling Wu; Jiehua Qiu; Hui Wen; Fucheng Lin; Zeng Tao; Chaoxi Luo*; Yanjun Kou*; UvKmt6-mediated H3K27 trimethylation is required for development, pathogenicity and stress response in Ustilaginoidea virens, Virulence, 2021,12(1): 2972-2988. 当年影响因子 5.428

17. Huanbin Shi#; Shuai Meng#; Jiehua Qiu#; Congcong Wang; Yazhou Shu; Chaoxi Luo; Yanjun Kou*; MoWhi2 regulates appressorium formation and pathogenicity via the MoTor signalling pathway in Magnaporthe oryzae, Molecular Plant Pathology, 2021, 22(8): 969–983. 当年影响因子 5.520

18. Zhiquan Liu; Yujun Zhu; Huanbin Shi; Jiehua Qiu; Xinhua Ding; Yanjun Kou*; Recent progress in rice broad-spectrum disease resistance, International Journal of Molecular Sciences, 2021, 22(21):11658. 当年影响因子 6.208

19. 沈浙南#; 时焕斌#; 邱结华; 王聪聪; 孟帅; 寇艳君*；江苏省 212 份水稻材料中抗稻瘟病基因Pi2/Pi9/Piz-t/Pigm的情况分析，分子植物育种，2021，https://kns.cnki.net/kcms/detail/46.1068.S.20210413.1020.002.html

20. 沈浙南#; 邱结华#; 解军辉; 时焕斌; 寇艳君*; 浙江省主栽水稻品种抗稻瘟病基因的分子检测,中国稻米, 2021,27(06):28-33.

21. Jiehua Qiu#; Feifei Lu#; Hong Wang; Junhui Xie; Congong Wang; Zhiquan Liu; Shuai Meng; Huangbin Shi; Xihong Shen*; Yanjun Kou*; A candidate gene for the determination of rice resistant to rice false smut, Molecular Breeding, 2020, 40(12): 105. 当年影响因子 2.589

22. Shuai Meng; Meng Xiong; Jane Sadhna Jagernath; Congcong Wang; Jiehua Qiu; Huanbin Shi; Yanjun Kou*; UvAtg8-mediated autophagy regulates fungal growth, stress responses, conidiation, and pathogenesis in Ustilaginoidea virens, Rice, 2020, 13(1): 56. 当年影响因子 4.783

23. Meng Xiong#; Shuai Meng#; Jiehua Qiu; Huanbin Shi; Xiangling Shen*; Yanjun Kou*; Putative phosphatase UvPsr1 is required for mycelial growth, conidiation, stress response and pathogenicity in Ustilaginonidea virens, Rice Science, 2020, 27(6): 529-536. 当年影响因子 3.333

24. Yanjun Kou#*; Yunlong He#; Jiehua Qiu; Yazhou Shu; Fan Yang; Yizhen Deng; Naweed I. Naqvi*; Mitochondrial dynamics and mitophagy are necessary for proper invasive growth in rice blast, Molecular Plant Pathology, 2019, 20(8): 1147-1162. 当年影响因子 4.326

25. Jiehua Qiu; Shuai Meng; Yizhen Deng; Shiwen Huang; Yanjun Kou*; Ustilaginoidea Virens: A fungus infects rice flower and threats world rice production, Rice Science, 2019, 26(4): 199-206. (Journal cover features, invited review)  当年影响因子 3.162

26. 陈旭; 邱结华; 熊萌; 舒亚洲; 黄世文; 寇艳君*; 稻曲病研究进展, 中国稻米, 2019, 25(5): 30-36.

27. Yanjun Kou*; Jiehua Qiu; Zeng Tao*; Every coin has two sides: Reactive oxygen species during rice-Magnaporthe oryzae interaction, International Journal of Molecular Sciences, 2019, 20(5): 1191. (Invited review) 当年影响因子 4.556

28. Yanjun Kou*; Yi Han Tan; Ravikrishna Ramanujam; Naweed I. Naqvi*; Structure-function analyses of the Pth11 receptor reveal an important role for CFEM motif and redox regulation in rice blast, New Phytologist, 2017, 214(1): 330-342. 当年影响因子: 7.4

发明专利

1． 寇艳君; 陈娅; 邱结华; 时焕斌; 水稻OsHPP08基因在调控水稻对稻瘟病菌抗性中的应用; 2023-06-08, 中国, ZL202210764962.9

2． 寇艳君; 孟帅; 时焕斌; 邱结华; 水稻OsSTE24基因在提高水稻对稻瘟病菌抗性中的应用; 2023-04-28, 中国, ZL202111326383.8

3． 寇艳君; 陈娅; 邱结华; 时焕斌; 水稻OsPR6基因或其编码的蛋白在调控水稻对稻瘟病菌抗性中的应用; 2023-03-02, 中国, ZL202210763723.1

4． 寇艳君; 邱结华; 沈浙南; 时焕斌; 一种检测稻瘟病菌无毒基因AvrPi9致病性变异的引物组、试剂盒及方法, 2022-04-01, 中国, ZL202110101239.8

5． 寇艳君; 时焕斌; 王聪聪; 邱结华; 一种生防菌株ZL-1分离及其应用, 2022-03-18, 中国, ZL202110209600.9

6． 寇艳君; 孟帅; 时焕斌; 邱结华; 一种稻瘟病菌线粒体自噬相关的致病因子、基因及应用, 2021-04-16, 中国, ZL 2019 1 0881495.6

7． 寇艳君; 熊萌; 时焕斌; 邱结华; 一种负调控稻曲病菌产孢的致病因子、基因及应用; 2021-04-16, 中国, ZL 2019 1 0881514.5

8． 寇艳君; 矣林青; 杨宁; 孟帅; 一种对稻曲毒素A进行提取净化的预处理装置与方法, 2020-12-29, 中国, ZL 2020 1 0213247.7

课题组成员承担的国家级项目：

1. 水稻白叶枯病的生物防治，国家自然科学基金，国际(地区)合作与交流项目，执行期：2023.1.1-2024.12.31，主持人：寇艳君；

2. 稻瘟病菌膜蛋白与水稻抗菌肽互作机制及关键防控技术创新, 国家重点研发计划，青年科学家项目，执行期：2022.9.1-2025.12.31，主持人：寇艳君；

3. OsAEL1调控水稻抗稻瘟病的分子机制及育种初步应用，国家自然科学基金，面上项目，32171944，执行期：2022.1.1-2025.12.31，主持人：寇艳君；

4. MoWhi2调控MoUth1介导的线粒体自噬分子机制研究，国家自然科学基金，青年基金，32100161，执行期：2022.1.1-2024.12.31，主持人：邱结华；

5. MoRpi2调控TOR信号途径介导稻瘟病菌附着胞形成的机制研究，国家自然科学基金，青年基金，32000103，执行期：2021.1.1-2023.12.31，主持人：寇艳君；

6. 泛素连接酶MoSkp1/MoCul1/MoFwd1调控稻瘟病菌分生孢子萌发和致病力的分子机制研究, 国家自然科学基金，青年基金，31900127, 执行期：2020.1.1-2022.12.31，主持人：时焕斌。

课题组工作人员：

研究与技术人员：寇艳君、邱结华、时焕斌、蒋楠

备注：本课题组正在招聘工作人员（博士毕业，有编制）、硕士和博士研究生及博士后，期待您的加入。联系电话：0571-63501170；邮箱：kouyanjun@caas.cn