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State Key Laboratory of Rice Biology

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  • Dr. Wang Kejian

    Professor

    State Key Laboratory of Rice Biology

    China National Rice Research Institute (CNRRI)

    Address: No. 359, Tiyuchang Rd., Hangzhou 310006, P.R. China

    Phone: +86-571-63370202

    Fax: +86-571-63370202

    E-mail: wangkejian@caas.cn

Education Background


Kejian Wang was received his Bachelor Degree of Agronomy from Yangzhou University, China in 2004, and PhD of Science from Institute of Genetics and Developmental Biology of Chinese Academy of Sciences in 2009.


Professional Experience

2009-2011 Research assistant, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.

2012-2013 Research associate, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.

2013-Present Professor, China National Rice Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou, China.


Research Area


1. Genome Editing

Genome editing enables precise and efficient targeted modification of an organism’s genome. Our lab is interested in developing novel genome editing systems and applying the systems for both basic research and crop improvement.

2. Apomixis

Apomixis is a process that allows clonal reproduction through seeds, resulting in offspring that are genetically identical to the mother plant. The introduction of apomixis into major crops will have revolutionary implications for agriculture. Recently, our studies have shown that apomixis is possible in hybrid rice. Now our lab is trying to optimize present apomixis strategy and hope to permanently fix hybrid vigor in crops.

3. Genetic Recombination

Genetic recombination is the process that produces new gene combinations that differ from those of either parent. Our lab is interested in investigating the mechanism of genetic recombination. The long-term goal of our research is to gain control of the occurrence of recombination and create novel allele combination of genetic variation in crops.



    1. Publications

    • Research Paper

      1.Wang, C., Liu, Q., Shen, Y., Hua, Y., Wang, J., Lin, J., Wu, M., Sun, T., Cheng, Z., Mercier, R., and Wang, K. (2019). Clonal seeds from hybrid rice by simultaneous genome engineering of meiosis and fertilization genes. Nature Biotechnology 37, 283-286. (Cover Story)

      2.Wang, C., and Wang, K. (2019). Rapid Screening of CRISPR/Cas9-Induced Mutants Using the ACT-PCR Method. Methods in Molecular Biology (Clifton, NJ) 1917, 27-32.

      3.Wang, J., Meng, X., Hu, X., Sun, T., Li, J., Wang, K*., and Yu, H*. (2019). xCas9 expands the scope of genome editing with reduced efficiency in rice. Plant Biotechnology Journal 4, 709-711

      4.Wang, J., Wang, C., and Wang, K. (2019). Generation of marker-free transgenic rice using CRISPR/Cas9 system controlled by floral specific promoters. Journal of Genetics and Genomics 46, 61-64.

      5.Li, S., Shen, L., Hu, P., Liu, Q., Zhu, X., Qian, Q., Wang, K*., and Wang, Y*. (2019). Developing disease-resistant thermosensitive male sterile rice by multiplex gene editing. Journal of Integrative Plant Biology

      6.Liu, Q., Wang, C., Jiao, X., Zhang, H., Song, L., Li, Y., Gao, C., and Wang, K*. (2019). Hi-TOM: a platform for high-throughput tracking of mutations induced by CRISPR/Cas systems. Science China Life sciences. 62, 1-7 (Cover Story)

      7.Ren, J., Hu, X.., Wang, K., and Wang, C. (2019). Development and Application of CRISPR/Cas System in Rice. Rice Science 26, 69-76.

      8.Zhan, N., Wang, C., Chen, L., Yang, H., Feng, J., Gong, X., Ren, B., Wu, R., Mu, J., Li, Y., Liu, Z., Zhou, Y., Peng, J., Wang, K., Huang, X., Xiao, S., and Zuo, J*. (2018). S-Nitrosylation Targets GSNO Reductase for Selective Autophagy during Hypoxia Responses in Plants. Mol Cell 71, 142-154 e146.

      9.Hu, X., Meng, X., Liu, Q., Li, J*., and Wang, K*. (2018). Increasing the efficiency of CRISPR-Cas9-VQR precise genome editing in rice. Plant Biotechnology Journal 16, 292-297.

      10.Shen, L., Wang, C., Fu, Y., Wang, J., Liu, Q., Zhang, X., Yan, C*., Qian, Q*., and Wang, K*. (2018). QTL editing confers opposing yield performance in different rice varieties. Journal of Integrative Plant Biology 61, 122-125. (Cover Story)

      11.Shen, L., Hua, Y., Fu, Y., Li, J., Liu, Q., Jiao, X., Xin, G., Wang, J., Wang, X., Yan, C*., and Wang, K* (2017). Rapid generation of genetic diversity by multiplex CRISPR/Cas9 genome editing in rice. Science China Life sciences 60, 506-515.

      12.Hu, X., Wang, C., Liu, Q., Fu, Y., and Wang, K*. (2017). Targeted mutagenesis in rice using CRISPR-Cpf1 system. Journal of Genetics and Genomics 44, 71-73.

      13.Meng, X., Hu, X., Liu, Q., Song, X., Gao, C., Li, J*., and Wang, K*. (2017). Robust genome editing of CRISPR-Cas9 at NAG PAMs in rice. Science China Life sciences. 61: 122-125

      14.Hua, Y., Wang, C., Huang, J., and Wang, K*. (2017). A simple and efficient method for CRISPR/Cas9-induced mutant screening. Journal of Genetics and Genomics 44, 207-213.

      15.Hu, X., Wang, C., Fu, Y., Liu, Q., Jiao, X., and Wang, K*. (2016). Expanding the Range of CRISPR/Cas9 Genome Editing in Rice. Molecular Plant 9, 943-945.

      16.Wang, C., Shen, L., Fu, Y., Yan, C., and Wang, K*. (2015). A Simple CRISPR/Cas9 System for Multiplex Genome Editing in Rice. Journal of Genetics and Genomics 42, 703-706.

      17.Wang, K*., Wang, C., Liu, Q., Liu, W., and Fu, Y. (2015). Increasing the Genetic Recombination Frequency by Partial Loss of Function of the Synaptonemal Complex in Rice. Molecular Plant 8, 1295-1298.

      18.Che, L., Wang, K., Tang, D., Liu, Q., Chen, X., Li, Y., Hu, Q., Shen, Y., Yu, H., Gu, M., et al. (2014). OsHUS1 facilitates accurate meiotic recombination in rice. PLoS genetics 10, e1004405-e1004405.

      19.Ji, J., Tang, D., Wang, M., Li, Y., Zhang, L., Wang, K., Li, M., and Cheng, Z*. (2013). MRE11 is required for homologous synapsis and DSB processing in rice meiosis. Chromosoma 122, 363-376.

      20.Wu, X., Tang, D., Li, M., Wang, K., and Cheng, Z*. (2013). Loose Plant Architecture1, an INDETERMINATE DOMAIN Protein Involved in Shoot Gravitropism, Regulates Plant Architecture in Rice. Plant Physiology 161, 317-329.

      21.Hong, L., Tang, D., Shen, Y., Hu, Q., Wang, K., Li, M., Lu, T., and Cheng, Z*. (2012). MIL2 (MICROSPORELESS2) regulates early cell differentiation in the rice anther. New Phytologist 196, 402-413.

      22.Hong, L., Qian, Q., Tang, D., Wang, K., Li, M., and Cheng, Z*. (2012). A mutation in the rice chalcone isomerase gene causes the golden hull and internode 1 phenotype. Planta 236, 141-151.

      23.Hong, L., Tang, D., Zhu, K., Wang, K., Li, M., and Cheng, Z*. (2012). Somatic and reproductive cell development in rice anther is regulated by a putative glutaredoxin. The Plant Cell 24, 577-588.

      24.Ji, J., Tang, D., Wang, K., Wang, M., Che, L., Li, M., and Cheng, Z*. (2012). The role of OsCOM1 in homologous chromosome synapsis and recombination in rice meiosis. Plant J 72, 18-30.

      25.Luo, Q., Tang, D., Wang, M., Luo, W., Zhang, L., Qin, B., Shen, Y., Wang, K., Li, Y., and Cheng, Z*. (2012). The role of OsMSH5 in crossover formation during rice meiosis. Molecular Plant 6, 729-742

      26.Shen, Y., Tang, D., Wang, K., Wang, M., Huang, J., Luo, W., Luo, Q., Hong, L., Li, M., and Cheng, Z*. (2012). ZIP4 in homologous chromosome synapsis and crossover formation in rice meiosis. Journal of cell science 125, 2581-2591.

      27.Wang, K., Wang, M., Tang, D., Shen, Y., Miao, C., Hu, Q., Lu, T., and Cheng, Z*. (2012). The role of rice HEI10 in the formation of meiotic crossovers. PLoS Genet 8, e1002809.

      28.Wang, M., Tang, D., Luo, Q., Jin, Y., Shen, Y., Wang, K., and Cheng, Z*. (2012). BRK1, a Bub1-Related Kinase, Is Essential for Generating Proper Tension between Homologous Kinetochores at Metaphase I of Rice Meiosis. The Plant cell 24, 4961-4973.

      29.Che, L., Tang, D., Wang, K., Wang, M., Zhu, K., Yu, H., Gu, M., and Cheng, Z. (2011). OsAM1 is required for leptotene-zygotene transition in rice. Cell Res 21, 654-665.

      30.Li, M., Tang, D., Wang, K., Wu, X., Lu, L., Yu, H., Gu, M., Yan, C., and Cheng, Z. (2011). Mutations in the F-box gene LARGER PANICLE improve the panicle architecture and enhance the grain yield in rice. Plant biotechnology journal 9, 1002-1013.

      31.Qin, B.X., Tang, D., Huang, J., Li, M., Wu, X.R., Lu, L.L., Wang, K.J., Yu, H.X., Chen, J.M., Gu, M.H., et al. (2011). Rice OsGL1-1 is involved in leaf cuticular wax and cuticle membrane. Mol Plant 4, 985-995.

      32.Shao, T., Tang, D., Wang, K., Wang, M., Che, L., Qin, B., Yu, H., Li, M., Gu, M., and Cheng, Z. (2011). OsREC8 is essential for chromatid cohesion and metaphase I monopolar orientation in rice meiosis. Plant Physiol 156, 1386-1396.

      33.Wang, M., Tang, D., Wang, K., Shen, Y., Qin, B., Miao, C., Li, M., and Cheng, Z. (2011). OsSGO1 maintains synaptonemal complex stabilization in addition to protecting centromeric cohesion during rice meiosis. Plant J 67, 583-594.

      34.Wang, K., Wang, M., Tang, D., Shen, Y., Qin, B., Li, M., and Cheng, Z. (2011). PAIR3, an axis-associated protein, is essential for the recruitment of recombination elements onto meiotic chromosomes in rice. Mol Biol Cell 22, 12-19.

      35.Wang, K., Tang, D., Hong, L., Xu, W., Huang, J., Li, M., Gu, M., Xue, Y., and Cheng, Z. (2010). DEP and AFO regulate reproductive habit in rice. PLoS genetics 6, e1000818.

      36.Wang, M., Wang, K., Tang, D., Wei, C., Li, M., Shen, Y., Chi, Z., Gu, M., and Cheng, Z. (2010). The central element protein ZEP1 of the synaptonemal complex regulates the number of crossovers during meiosis in rice. The Plant Cell 22, 417-430.

      37.Yu, H., Wang, M., Tang, D., Wang, K., Chen, F., Gong, Z., Gu, M., and Cheng, Z. (2010). OsSPO11-1 is essential for both homologous chromosome pairing and crossover formation in rice. Chromosoma 119, 625-636.

      38.Wang, K., Tang, D., Wang, M., Lu, J., Yu, H., Liu, J., Qian, B., Gong, Z., Wang, X., Chen, J., et al. (2009). MER3 is required for normal meiotic crossover formation, but not for presynaptic alignment in rice. Journal of cell science 122, 2055-2063.




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