硕士生导师简介
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胡时开 专业学科：作物遗传育种 研究方向：分子育种 |
胡时开，博士，研究员，博士研究生导师，主要从事优质抗病新种质创制和新品种培育、稻米营养安全品质遗传改良等工作。现任农业生物育种国家科技重大专项技术首席，先后主持农业生物育种国家科技重大专项课题、国家自然科学基金（3项）、浙江省农业关键核心技术攻关重大项目、浙江省自然科学基金重大项目以及其他省部级以上项目共计10余项；获神农中华农业科技奖1项，参与培育优质抗病水稻新品种10余个，获植物新品种权7项，国家授权专利16项；以第一作者或通讯作者（含共同）在Molecular Plant、Plant Biotechnology Journal、Journal of Hazardous Materials、Plant Physiology等国内外刊物上发表研究论文40余篇，参与《水稻分子育种技术指南》的撰写；入选国家高层次人才，浙江省高层次人才，中国农业科学院杰出青年英才。
主要研究方向：
1. 水稻优质抗病关键基因挖掘、种质创制及品种培育；
2. 稻米营养与安全品质关键基因挖掘及育种利用。
承担项目：
1. 浙江省农业科技重大项目，主持，执行期2024-2028，经费3025万元。
2. 农业生物育种国家科技重大专项，主持，执行期2022-2025，经费15176万元。
3. 浙江省自然科学基金重大项目/青年原创项目，主持，执行期2023-2025，经费100万元。
4. 中国农业科学院“农科英才”杰出青年英才，主持，执行期2024-2028，经费500万元。
5. 国家自然科学基金面上项目，主持，32071991，执行期2021-2024，经费58万元。
6. 国家自然科学基金面上项目，主持，31872861，执行期2019-2022，经费60万元。
7. 国家自然科学基金委面上项目，主要参与者/负责项目执行，31972961，执行期2020-2023，经费58万元。
8. 国家自然科学基金委 青年科学基金，主持，31501279，执行期2016-2018，经费24万元。
9. 浙江省重点研发“尖兵计划”，主要参与者/负责项目执行，2022C02011，执行期2022-2024，经费2000万元。
10. 浙江省重点研发计划课题，主持，2021C02056-1，执行期2021-2023，经费95万元。
11. 转基因生物新品种培育重大专项，参加/负责项目执行，2016ZX08001006-003，执行期2016-2020，经费530.99万元。
12. 中央级公益性科研院所基本科研业务费专项，主持，CPSIBRF-CNRRI-202103，执行期2021-2023，经费91.5万元。
13. 水稻生物学国家重点实验室自主研究课题，主持，2020ZZKT10202，执行期2020-2025，经费112万元。
代表性成果：
1. 胡时开，胡培松，唐绍清，等.一种稻米营养品质调控基因OsVE1及其编码的蛋白质的应用，2024年授权发明专利，ZL 2022 1 0494929.9；
2. 胡时开，胡培松，钱前，等. 一种水稻株型调控相关基因、蛋白质和应用，2021年授权发明专利，ZL201910194712.4；
3. 胡时开，钱前，郭龙彪，等. 一种植物花粉特异性启动子PSP1及其应用，2020年授权发明专利，ZL201710822827.4；
4. 胡时开，胡培松，郭龙彪，等. 一种水稻叶绿体发育调控基因AHS1及其编码的蛋白质与应用，2019年授权发明专利，ZL201710817590.0；
5. 胡培松，胡时开，唐绍清，等. 一种水稻叶片衰老和穗型调控基因HK73及其编码的蛋白质、分子标记与应用，2021年授权发明专利，ZL201811636548.X;
6. 胡培松，唐绍清，胡时开，等. 一种快速高效筛选水稻基因编辑株系中无转基因成分植株的方法，2021年授权发明专利，ZL201910172486.X；
7. 胡培松，胡时开，唐绍清，等. 试剂盒（稻米叶酸含量检测），2022年授权外观设计专利，ZL202230136625.6；
8. 郭龙彪，钱前，胡时开，等. 水稻植株形态建成调控基因PTH1及其应用，2015年授权发明专利，ZL201310602467.9；
9.水稻品质遗传改良团队，2019年中华农业科技奖优秀创新团队奖，第十完成人。
代表性论文(# 共一作者，* 通讯作者)：
1. Shikai Hu *, #, Lingwei Yang #, Jinyang Cai #, Guiai Jiao, Hailong Yang, Suozhen Hui, Liang Zhou, Ruijie Cao, Jingxin Wang, Yujuan Chen, Junchao Fang, Zhonghua Sheng, Shaoqing Tang*, Peisong Hu*. Production of Grains with Low-glutelin and High Eating Quality by using Dominant Allele Lgc-1 in Three-line Japonica Hybrid Rice. Plant Biotechnology Journal, 2025, 23(2)：374-376. DOI: 10.1111/pbi.14502.
2. Shikai Hu#, *, Liang Zhou#, Jingxin Wang, Amos Musyoki Mawia, Suozhen Hui, Bo Xu, Guiai Jiao, Zhonghua Sheng, Gaoneng Shao, Xiangjin Wei, Ling Wang, Lihong Xie, Fengli Zhao, Shaoqing Tang*, Peisong Hu*. Production of Grains with Ultra-low Heavy Metal Accumulation by Pyramiding Novel Alleles of OsNramp5 and OsLsi2 in Two-line Hybrid Rice. Plant Biotechnology Journal, 2024, 22(10): 2921-2931.
3. Shikai Hu, Xingming Hu, Jiang Hu, Lianguang Shang, Guojun Dong, Dali Zeng, Longbiao Guo, Qian Qian*. Xiaowei, A New Rice Germplasm for Large-Scale Indoor Research. Molecular Plant, 2018, 11(11): 1418-1420.
4. Yujuan Chen#, Suozhen Hui#, Huijuan Li#, Guiai Jiao, Ruijie Cao, Liang Zhou, Jingxin Wang, Amos Musyoki Mawia, Lingwei Yang, Yu Wu, Yuanyaun Zhang, Zhonghua Sheng, Gaoneng Shao, Fengli Zhao, Ling Wang, Yusong Lyu, Shaoqing Tang*, Shikai Hu*, Peisong Hu*. A MYB61-SWB9-KOs module regulates grain chalkiness via gibberellin biosynthesis in rice endosperm. Plant Biotechnology Journal, 2025, 23(7): 2793-2808.
5. Suozhen Hui #, Huijuan Li#, Amos Musyoki Mawia#, Liang Zhou, Jinyang Cai, Shakeel Ahmad, Changkai Lai, Jingxin Wang, Guiai Jiao, Lihong Xie, Gaoneng Shao, Zhonghua Sheng, Shaoqing Tang, Jianlong Wang, Xiangjin Wei*, Shikai Hu*, Peisong Hu*. Production of aromatic three-line hybrid rice using novel alleles of BADH2. Plant Biotechnology Journal, 2022, 20(1): 59-74.
6. Jingxin Wang#, Lingwei Yang#, Bo Xu#, Ruijie Cao, Sidra Charagh, Suozhen Hui, Liang Zhou, Yuanyuan Zhang, Yujuan Chen, Zhonghua Sheng, Guiai Jiao, Gaoneng Shao, Ling Wang, Fengli Zhao, Lihong Xie, Yusong Lyu, Shaoqing Tang*, Shikai Hu*, Peisong Hu*. Chloroplast-localized transporter OsNTP1 mediates cadmium transport from root to shoot and sugar metabolism in rice. Journal of Hazardous Materials, 2025, 484: 136766 . https://doi.org/10.1016/j.jhazmat.2024.136766.
7. Amos Musyoki Mawia#, Suozhen Hui#, Liang Zhou#, Huijuan Li, Javaria Tabassum, Changkai Lai, Jingxin Wang, Gaoneng Shao, Xiangjin Wei, Shaoqing Tang, Ju Luo*, Shikai Hu*, Peisong Hu*. Inorganic Arsenic Toxicity and Alleviation Strategies in Rice. Journal of Hazardous Materials, 2021, 408：124751.
8. Sidra Charagh#, Jingxin Wang#, Suozhen Hui#, Ali Raza, Ruijie Cao, Liang Zhou, Lingwei Yang, Bo Xu, Yuanyuan Zhang, Amos Musyoki Mawia, Zhonghua Sheng, Shaoqing Tang, Shikai Hu*, Peisong Hu*. Smart reprogramming of plants against cadmium toxicity using membrane transporters and modern tools. Plant Physiology and Biochemistry , 2025, 224: 109919.
9. Ting Mao#, Mingdong Zhu#, Zhonghua Sheng, Gaoneng Shao, Guiai Jiao, Amos Musyoki Mawia, Shakeel Ahmad, Lihong Xie, Shaoqing Tang, Xiangjin Wei, Shikai Hu*, Peisong Hu*. Effects of grain shape genes editing on appearance quality of erect-panicle Geng/Japonica rice. Rice, 2021, 14, 74.
10. Lingwei Yang#，Junchao Fang#，Jingxin Wang#，Suozhen Hui，Liang Zhou，Bo Xu，Yujuan Chen，Yuanyuan Zhang，Changkai Lai，Guiai Jiao, Zhonghua Sheng, Xiangjin Wei, Gaoneng Shao, Lihong Xie, Ling Wang, Ying Chen, Fengli Zhao, Shikai Hu*, Peisong Hu*, Shaoqing Tang* . Genome-Wide Identification and Expression Analysis of 3-Ketoacyl-CoA Synthase Gene Family in Rice (Oryza sativa L.) Under Cadmium Stress. Frontiers in Plant Science, 2023, 14:1222288. doi: 10.3389/fpls.2023.1222288.
11. Mao Ting, Li Xin, Liu Yan, Zhong Shuncheng, Wang Shiyu, Li Xu, Hu Shikai*. (2023) Effect of GW8 Gene Editing on the Appearance Quality of Erect-panicle Type (dep1) Japonica Rice. Rice Science, 2023, 30(5): 359−363.
12. Shakeel Ahmad, Javaria Tabassum, Zhonghua Sheng, Yusong Lv, Wei Chen, Aqib Zeb, Nannan Dong, Gaoneng Shao, Xiangjin Wei, Shikai Hu*, Shaoqing Tang*. Loss-of-function of PGL10 impairs photosynthesis and tolerance to high-temperature stress in rice. Physiologia Plantarum. 2024, 176:e14369.
13. Sidra Charagh, Suozhen Hui, Jingxin Wang, Ali Raza, Liang Zhou, Bo Xu, Yuanyuan Zhang, Zhonghua Sheng, Shaoqing Tang, Shikai Hu*, Peisong Hu*.Unveiling Innovative Approaches to Mitigate Metals/Metalloids Toxicity for Sustainable Agriculture. Physiologia Plantarum, 2024, 176:e14226.
14. Sidra Charagh#, Hong Wang#, Jingxin Wang, Ali Raza,Suozhen Hui,Ruijie Cao, Liang Zhou,Shaoqing Tang, Peisong Hu*,Shikai Hu*. Leveraging multi-omics tools to comprehend responses and tolerance mechanisms of heavy metals in crop plants. Functional & Integrative Genomics, 2024, 24:194.https://doi.org/10.1007/s10142-024-01481-1.
15. Shakeel Ahmad#, Liqun Tang#, Rahil Shahzad, Amos Musyoki Mawia, Gundra Sivakrishna Rao, Shakra Jamil, Chen Wei, Zhonghua Sheng, Gaoneng Shao, Xiangjin Wei, Peisong Hu, Magdy M. Mahfouz, Shikai Hu*, Shaoqing Tang*. (2021) CRISPR-based crop improvements: A way forward to achieve zero hunger. Journal of Agricultural and Food Chemistry, 69 (30), 8307-8323.
16. Liwen Wu#, Deyong Ren#, Shikai Hu#, Gengmi Li#, Guojun Dong, Liang Jiang, Xingming Hu, Weijun Ye, Yongtao Cui, Li Zhu, Jiang Hu, Guangheng Zhang, Zhenyu Gao, Dali Zeng, Qian Qian*, and Longbiao Guo*. Down-regulation of a nicotinate phosphoribosyltransferase gene, OsNaPRT1, leads to withered leaf tips. Plant Physiology, 2016, 171: 1085-1098.
17. Shikai Hu#, Guojun Dong#, Jie Xu, Yan Su, Zhengyuan Shi, Weijun Ye, Yuanyuan Li, Gengmi Li, Bin Zhang, Jiang Hu, Qian Qian, Dali Zeng*, Longbiao Guo*. A point mutation in the zinc finger motif of RID1/EHD2/OsID1 protein leads to outstanding yield-related traits in japonica rice variety Wuyunjing 7. Rice, 2013, 6: 24.
18. Su Yan#, Rao YuChun#, Hu Shikai#, Yang Yaolong, Gao Zhenyu, Zhang Guangheng, Liu Jian, Hu Jiang, Yan Meixian, Dong Guojun, Zhu Li, Guo Longbiao, Qian Qian*, Zeng Dali*. Map-based cloning proves qGC-6, a major QTL for gel consistency of japonica/indica cross, was responded by Waxy in rice (Oryza sativa L.). Theoretical and Applied Genetics, 2011, 123: 859-867.
19. Weijun Ye#, Shikai Hu#, Liwen Wu, Changwei Ge, Yongtao Cui, Ping Chen, Jie Xu, Deyong Ren, Guojun Dong, Longbiao Guo* and Qian Qian*. White Stripe Leaf 12 (WSL12), encoding a nucleoside diphosphate kinase 2 (OsNDPK2), regulates chloroplast development and abiotic stress response in rice (Oryza sativa L.). Molecular Breeding, 2016, 36: 57.
20. Yan Su#, Shikai Hu#, Bin Zhang, Weijun Ye, Yaofang Niu, Longbiao Guo*, Qian Qian*. Characterization and fine mapping of a new early leaf senescence mutant es3(t) in rice. Plant Growth Regulation, 2017, 81: 419-431.
21. Weijun Ye#, Shikai Hu#, Liwen Wu, Changwei Ge, Yongtao Cui, Ping Chen, Jing Xu, Guojun Dong, Longbiao Guo*, Qian Qian*. Fine mapping a major QTL qFCC7L for chlorophyll content in rice (Oryza sativa L.) cv. PA64s. Plant Growth Regulation, 2017, 81: 81-90.
22. Haiyan Lin#, Shikai Hu#, Ruifang Liu, Ping Chen, Changwei Ge, Bo Zhu, Longbiao Guo*. Genome sequence of Pseudomonas koreensis CRS05-R5, an antagonistic bacterium isolated from rice paddy field. Frontiers in Microbiology, 2016, 7: 1756.
23. 胡时开, 胡培松*. 功能稻米研究现状与展望. 中国水稻科学, 2021, 35(4): 311-325.
通讯地址：浙江省杭州市体育场路359号，中国水稻研究所
电 话： 0571-63370482
电子邮箱：hushikai@caas.cn
（内容更新于2025年12月20日）
