博士生导师简介
胡时开 专业学科:作物遗传育种 研究方向:分子育种 |
胡时开,博士,研究员,博士生导师,主要从事优质抗病新种质创制和新品种培育、稻米营养安全品质遗传改良等工作。现任国家农业科技重大项目首席科学家,先后主持国家农业科技重大项目课题1项、国家自然科学基金3项、浙江省自然科学基金重大项目1项以及其他省部级以上项目共计10余项;获神农中华农业科技奖1项,参与培育优质抗病水稻新品种9个,获植物新品种权2项,国家授权专利11项;以第一作者或通讯作者(含共同)在Molecular Plant、Plant Biotechnology Journal、Journal of Hazardous Materials、Plant Physiology等国内外刊物上发表研究论文20余篇,参与《水稻分子育种技术指南》的撰写;入选中国农业科学院青年英才,浙江省高层次人才特殊支持计划青年拔尖人才,国家高层次人才特殊支持计划青年拔尖人才。
主要研究方向:
1. 水稻优质抗病关键基因挖掘、种质创制及品种培育;
2. 稻米营养与安全品质关键基因挖掘及育种利用。
承担项目:
1. 国家自然科学基金面上项目,主持,32071991,执行期2021-2024,经费58万元。
2. 中国农业科学院“青年英才”培育工程项目,主持,NKYCQN-2021-29,执行期2022-2027,经费300万。
3. 国家自然科学基金面上项目,主持,31872861,执行期2019-2022,经费60万元。
4. 浙江省自然科学基金重大项目/青年原创项目,主持,执行期2023-2025,经费100万元。
5. 水稻生物学国家重点实验室自主研究课题,主持,2020ZZKT10202,执行期2020-2025,经费112万元。
6. 中央级公益性科研院所基本科研业务费专项,主持,CPSIBRF-CNRRI-202103,执行期2021-2023,经费91.5万元。
7. 国家自然科学基金委 青年科学基金,主持,31501279,执行期2016-2018,经费24万元。
8. 国家自然科学基金委面上项目,主要参与者/负责项目执行,31972961,执行期2020-2023,经费58万元。
9. 转基因生物新品种培育重大专项,参加/负责项目执行,2016ZX08001006-003,执行期2016-2020,经费530.99万元。
10. 浙江省重点研发计划课题,主持,2021C02056-1,执行期2021-2023,经费95万元。
11. 浙江省重点研发“尖兵计划”,参加/负责项目执行,2022C02011,执行期2022-2024,经费2000万元。
代表性成果:
1.水稻品质遗传改良团队,2019年中华农业科技奖优秀创新团队奖,第十完成人;
2. 胡时开,胡培松,钱前,等. 一种水稻株型调控相关基因、蛋白质和应用,2021年授权发明专利,ZL201910194712.4;
3. 胡时开,钱前,郭龙彪,等. 一种植物花粉特异性启动子PSP1及其应用,2020年授权发明专利,ZL201710822827.4;
4. 胡时开,胡培松,郭龙彪,等. 一种水稻叶绿体发育调控基因AHS1及其编码的蛋白质与应用,2019年授权发明专利,ZL201710817590.0;
5. 胡培松,胡时开,唐绍清,等. 一种水稻叶片衰老和穗型调控基因HK73及其编码的蛋白质、分子标记与应用,2021年授权发明专利,ZL201811636548.X;
6. 胡培松,唐绍清,胡时开,等. 一种快速高效筛选水稻基因编辑株系中无转基因成分植株的方法,2021年授权发明专利,ZL201910172486.X。
7. 胡培松,胡时开,唐绍清,等. 试剂盒(稻米叶酸含量检测),2022年授权外观设计专利,ZL202230136625.6;
8. 郭龙彪,钱前,胡时开,等. 水稻植株形态建成调控基因PTH1及其应用,2015年授权发明专利,ZL201310602467.9。
代表性论文(# 共一作者,* 通讯作者):
1. Shikai Hu, Xingming Hu, Jiang Hu, Lianguang Shang, Guojun Dong, Dali Zeng, Longbiao Guo, Qian Qian*. Xiaowei, A New Rice Germplasm for Large-Scale Indoor Research. Molecular Plant, 2018, 11(11): 1418-1420.
2. Suozhen Hui #, Huijuan Li#, Amos Musyoki Mawia#, Liang Zhou, Jinyang Cai, Shakeel Ahmad, Changkai Lai, Jingxin Wang, Guiai Jiao, Lihong Xie, Gaoneng Shao, Zhonghua Sheng, Shaoqing Tang, Jianlong Wang, Xiangjin Wei*, Shikai Hu*, Peisong Hu*. Production of aromatic three-line hybrid rice using novel alleles of BADH2. Plant Biotechnology Journal, 2022, 20(1): 59-74.
3. Amos Musyoki Mawia#, Suozhen Hui#, Liang Zhou#, Huijuan Li, Javaria Tabassum, Changkai Lai, Jingxin Wang, Gaoneng Shao, Xiangjin Wei, Shaoqing Tang, Ju Luo*, Shikai Hu*, Peisong Hu*. Inorganic Arsenic Toxicity and Alleviation Strategies in Rice. Journal of Hazardous Materials, 2021, 408:124751.
4. Ting Mao#, Mingdong Zhu#, Zhonghua Sheng, Gaoneng Shao, Guiai Jiao, Amos Musyoki Mawia, Shakeel Ahmad, Lihong Xie, Shaoqing Tang, Xiangjin Wei, Shikai Hu*, Peisong Hu*. Effects of grain shape genes editing on appearance quality of erect-panicle Geng/Japonica rice. Rice, 2021, 14, 74.
5. Shakeel Ahmad#, Liqun Tang#, Rahil Shahzad, Amos Musyoki Mawia, Gundra Sivakrishna Rao, Shakra Jamil, Chen Wei, Zhonghua Sheng, Gaoneng Shao, Xiangjin Wei, Peisong Hu, Magdy M. Mahfouz, Shikai Hu*, Shaoqing Tang*. (2021) CRISPR-based crop improvements: A way forward to achieve zero hunger. Journal of Agricultural and Food Chemistry, 69 (30), 8307-8323.
6. Lingwei Yang#,Junchao Fang#,Jingxin Wang#,Suozhen Hui,Liang Zhou,Bo Xu,Yujuan Chen,Yuanyuan Zhang,Changkai Lai,Guiai Jiao, Zhonghua Sheng, Xiangjin Wei, Gaoneng Shao, Lihong Xie, Ling Wang, Ying Chen, Fengli Zhao, Shikai Hu*, Peisong Hu*, Shaoqing Tang*. (2023) Genome-Wide Identification and Expression Analysis of 3-Ketoacyl-CoA Synthase Gene Family in Rice (Oryza sativa L.) Under Cadmium Stress. Frontiers in Plant Science. 14:1222288. doi: 10.3389/fpls.2023.1222288
7. Mao Ting, Li Xin, Liu Yan, Zhong Shuncheng, Wang Shiyu, Li Xu, Hu Shikai*. (2023) Effect of GW8 Gene Editing on the Appearance Quality of Erect-panicle Type (dep1) Japonica Rice. Rice Science, 2023, 30(5): 359−364.
8. Shikai Hu#, Guojun Dong#, Jie Xu, Yan Su, Zhengyuan Shi, Weijun Ye, Yuanyuan Li, Gengmi Li, Bin Zhang, Jiang Hu, Qian Qian, Dali Zeng*, Longbiao Guo*. A point mutation in the zinc finger motif of RID1/EHD2/OsID1 protein leads to outstanding yield-related traits in japonica rice variety Wuyunjing 7. Rice, 2013, 6: 24.
9. Liwen Wu#, Deyong Ren#, Shikai Hu#, Gengmi Li#, Guojun Dong, Liang Jiang, Xingming Hu, Weijun Ye, Yongtao Cui, Li Zhu, Jiang Hu, Guangheng Zhang, Zhenyu Gao, Dali Zeng, Qian Qian*, and Longbiao Guo*. Down-regulation of a nicotinate phosphoribosyltransferase gene, OsNaPRT1, leads to withered leaf tips. Plant Physiology, 2016, 171: 1085-1098.
10. Su Yan#, Rao YuChun#, Hu Shikai#, Yang Yaolong, Gao Zhenyu, Zhang Guangheng, Liu Jian, Hu Jiang, Yan Meixian, Dong Guojun, Zhu Li, Guo Longbiao, Qian Qian*, Zeng Dali*. Map-based cloning proves qGC-6, a major QTL for gel consistency of japonica/indica cross, was responded by Waxy in rice (Oryza sativa L.). Theoretical and Applied Genetics, 2011, 123: 859-867.
11. Weijun Ye#, Shikai Hu#, Liwen Wu, Changwei Ge, Yongtao Cui, Ping Chen, Jie Xu, Deyong Ren, Guojun Dong, Longbiao Guo* and Qian Qian*. White Stripe Leaf 12 (WSL12), encoding a nucleoside diphosphate kinase 2 (OsNDPK2), regulates chloroplast development and abiotic stress response in rice (Oryza sativa L.). Molecular Breeding, 2016, 36: 57.
12. Yan Su#, Shikai Hu#, Bin Zhang, Weijun Ye, Yaofang Niu, Longbiao Guo*, Qian Qian*. Characterization and fine mapping of a new early leaf senescence mutant es3(t) in rice. Plant Growth Regulation, 2017, 81: 419-431.
13. Weijun Ye#, Shikai Hu#, Liwen Wu, Changwei Ge, Yongtao Cui, Ping Chen, Jing Xu, Guojun Dong, Longbiao Guo*, Qian Qian*. Fine mapping a major QTL qFCC7L for chlorophyll content in rice (Oryza sativa L.) cv. PA64s. Plant Growth Regulation, 2017, 81: 81-90.
14. Haiyan Lin#, Shikai Hu#, Ruifang Liu, Ping Chen, Changwei Ge, Bo Zhu, Longbiao Guo*. Genome sequence of Pseudomonas koreensis CRS05-R5, an antagonistic bacterium isolated from rice paddy field. Frontiers in Microbiology, 2016, 7: 1756.
15. Yusong Lv, Gaoneng Shao, Guiai Jiao, Zhonghua Sheng, Lihong Xie, Shikai Hu, Shaoqing Tang, Xiangjin Wei* , Peisong Hu* . Targeted mutagenesis of POLYAMINE OXIDASE 5 that negatively regulates mesocotyl elongation enables the generation of direct-seeding rice with improved grain yield. Molecular Plant, 2021, 14: 344-351.
16. Lihong Xie , Shaoqing Tang , Xingjin Wei , Zhonghua Sheng , Gaoneng Shao , Guiai Jiao ,Shikai Hu , Lin Wang , Peisong Hu *. Simultaneous determination of apparent amylose, amylose and amylopectin content and classification of waxy rice using near-infrared spectroscopy (NIRS). Food Chemistry, 2022,388, 132944.
17. Ruijie Cao#, Shaolu Zhao#, Guiai Jiao, Yingqing Duan, Liuyang Ma, Nannan Dong, Feifei Lu, Mingdong Zhu, Gaoneng Shao, Shikai Hu, Zhonghua Sheng, Jian Zhang, Shaoqing Tang, Xiangjin Wei, Peisong Hu*. OPAQUE3, encoding a transmembrane bZIP transcription factor, regulates endosperm storage protein and starch biosynthesis in rice. Plant Communications, 2022, 3:100463.
18. 胡时开, 钱前*. RNA 解旋酶调控rRNA内稳态:水稻耐热新机制、分子育种新资源. 植物学报, 2016, 51 (3): 283-286.
19. 胡时开, 胡培松*. 功能稻米研究现状与展望. 中国水稻科学, 2021, 35(4): 311-325.
通讯地址:浙江省杭州市体育场路359号中国水稻研究所 310006
电话:0571-63370482
电子邮箱:hushikai@caas.cn
(内容更新于2023年11月20日)
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